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    Itching Itching is an unpleasant skin sensation that causes a desire to scratch. It is a self-protective response mechanism in the physiological state of the body and is one of the main symptoms of many skin diseases and systemic diseases.   Conduction pathway of itching When the skin is stimulated by pruritogenic substances, the itch receptors transmit nerve impulses to the posterior horn of the spinal cord, then through the spinothalamic tract to the thalamus, and finally to the somatosensory cortex. The special response patterns and projections formed in the periphery and the center are the neuroanatomical basis for the formation of itching. Itch receptors are a subtype of special unmyelinated nerve endings C fibers in the skin that are sensitive to histamine.         Histamine pathway     Among them, histamine, as one of the most common substances in the conduction mediators of itching, has been considered an important bioactive subst...

  I. Acne Skincare Market Status Global Market Overview: In 2024, the global acne skincare market size was approximately US\$30.4 billion (approximately RMB 218.4 billion), and is projected to reach US\$37.7 billion in 2031 (CAGR 3.1%). By product type: creams (40%) and lotions (30%) dominate the market, with acne patches showing the fastest growth (sales increased by 32.9% in 2023). Regional distribution: North America accounts for 35% (the largest market), with Asia-Pacific showing the fastest growth (CAGR 9.5%).   China Market Overview: The market size in 2023 was RMB 86.4 billion, with a CAGR of 7.3% from 2017 to 2023. It is expected to exceed RMB 95 billion in 2025. It accounts for approximately 40% of the global market share and is expected to further increase by 2031.   Core Growth Drivers: • High prevalence of acne:  The prevalence of acne in China is 8.1%, with nearly 9.4% of the global population affected, and 85% of adolescents. • Increased consumer awaren...